Neurometabolic Signatures of Cognitive Resilience in Alzheimer's Disease: A Hybrid 3D-MRSI/PET Study
Motivation: To explore neurometabolic features underlying cognitive resilience (CR) in Alzheimer's disease (AD). Goal(s): To identify the neurometabolic signatures of CR that mitigate AD-related glucose hypometabolism on cognition using combined 3D 1H-MRSI and PET imaging. Approach: We conducted high-resolution, whole-brain 1H-MRSI and 18F-FDG PET imaging with cognitive assessments in 245 participants (114 AD, 50 MCI and 81 controls). Interactions between neurometabolic changes and glucose hypometabolism across cognitive domains were analyzed. Results: Higher N-acetyl aspartate and lower myo-inositol levels in the temporal lobe mitigated the effects of hypometabolism on global cognitive function. Distinct neurometabolic changes support resilience across different cognitive domains. Impact: Higher NAA/Cr and lower mI/Cr levels in the parietal and temporal lobes may serve as promising markers of CR in AD. These neurometabolic signatures may provide insights into intervention strategies aimed at slowing cognitive decline in AD.
Authors
- Zhi‐Pei Liang (ORCID: https://orcid.org/0000-0003-4586-3056)
- Jialin Hu
- Yudu Li (ORCID: https://orcid.org/0000-0003-2061-2306)
- Miao Zhang (ORCID: https://orcid.org/0000-0002-4242-005X)
- Wenli Li (ORCID: https://orcid.org/0000-0002-3532-6444)
- Yaoyu Zhang (ORCID: https://orcid.org/0000-0001-9374-2502)
- Yao Li (ORCID: https://orcid.org/0000-0001-5009-7443)
- Wen Jin
- Yibo Zhao
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0567
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00