Utility of OGSE-Based Microstructural Parameters in Predicting Lymph Node Metastasis in Breast Cancer

Motivation: Accurate preoperative assessment of lymph node metastasis is vital in breast cancer treatment, but current imaging methods lack sufficient sensitivity, particularly for micrometastases. Goal(s): This study evaluates OGSE-derived MRI parameters to non-invasively distinguish metastatic from non-metastatic lymph nodes in breast cancer. Approach: We retrospectively analyzed OGSE microstructural parameters and ADC values in 109 patients, applying ROC and multivariate analyses for diagnostic performance. Results: Significant differences were observed in OGSE parameters and ADCs between groups, with combined predictors yielding high diagnostic accuracy. Impact: This study demonstrates that OGSE-based microstructural MRI parameters provide a reliable, non-invasive tool for assessing lymph node metastasis in breast cancer. These findings could enhance diagnostic accuracy, guide surgical decisions, and improve patient outcomes.