Macromolecular Proton Fraction Mapping of Subcortical Nuclei in Patients with Parkinson's Disease
Motivation: Imaging biomarkers are needed to detect neurodegeneration in the prodromal stage and predict disease progression in Parkinson's disease. Goal(s): To assess the utility of macromolecular proton fraction (MPF) mapping and quantitative susceptibility mapping (QSM) of subcortical nuclei for diagnosing Parkinson's disease. Approach: We performed MPF mapping and QSM in patients with Parkinson's disease and healthy controls. Results: In multiple subcortical nuclei, patients with Parkinson's disease showed significantly decreased MPF values and significantly increased magnetic susceptibility values compared with that in healthy controls. Impact: Decreased MPF may reflect neurodegeneration, while increased magnetic susceptibility suggests iron accumulation. Combining MPF and QSM measurements in subcortical nuclei could aid in diagnosing Parkinson's disease.
Authors
- Hiroyuki Kumazoe (ORCID: https://orcid.org/0000-0001-5177-790X)
- Hirohito Kan (ORCID: https://orcid.org/0000-0002-5688-2685)
- Yoshiaki Hirakawa (ORCID: https://orcid.org/0000-0001-6068-7957)
- Mika Kitajima (ORCID: https://orcid.org/0000-0002-6869-3638)
- Yasuhiro Fujiwara (ORCID: https://orcid.org/0000-0003-4831-444X)
- Nobutaka Sakae
- Kouta Miyamoto
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0584
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00