Clinical validation of a multi-modal ultra-fast MRI protocol for dementia diagnosis
Motivation: Despite the key role of MRI in dementia diagnosis and monitoring, long scan times limit accessibility and increase costs resulting in a disparity in care. Goal(s): To validate our sub-7-minute comprehensive MRI protocol incorporating Wave-CAIPI acceleration against a standard clinical 17-minute protocol, through multi-modal assessment. Approach: Validation through: (1) blinded neuroradiologist assessment, (2) automated brain morphometry comparison, and (3) white matter hyperintensity quantification. Results: Relative to the clinical standard, our ultra-fast protocol demonstrated non-inferiority with intra-rater kappa >0.80, volumetric differences <4%, and maintained WMH detection sensitivity, while reducing scan time from 17:39 min to 6:29 min. Impact: By significantly decreasing scan time, our validated ultra-fast protocol enables wider access to MRI for patients with dementia, whilst maintaining diagnostic utility, reducing healthcare costs and improving the patient experience.
Authors
- Geoff J.M. Parker (ORCID: https://orcid.org/0000-0003-2934-2234)
- Nick C. Fox (ORCID: https://orcid.org/0000-0002-6660-657X)
- Lloyd Prosser (ORCID: https://orcid.org/0000-0003-0299-1525)
- Dermot Mallon (ORCID: https://orcid.org/0000-0001-7434-1201)
- Daniel C. Alexander (ORCID: https://orcid.org/0000-0003-2439-350X)
- Carole H. Sudre (ORCID: https://orcid.org/0000-0001-5753-428X)
- Hans Rolf Jäger (ORCID: https://orcid.org/0000-0002-6403-4184)
- Bhavana Solanky (ORCID: https://orcid.org/0000-0002-5946-7604)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Catherine J. Mummery (ORCID: https://orcid.org/0000-0002-6739-0803)
- Ian B. Malone (ORCID: https://orcid.org/0000-0001-7512-7856)
- Miguel Rosa‐Grilo
- Emma Lim (ORCID: https://orcid.org/0000-0001-8073-1943)
- Haroon Chughtai
- David Thomas (ORCID: https://orcid.org/0000-0003-3684-9172)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0568
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00