Myelin water imaging in adolescent and young adult cancer patients and cognitive impairment: A feasibility longitudinal case-control study
Motivation: Brain MRI changes in adolescent and young adult cancer (AYAC) patients are underexplored. Goal(s): Evaluate value of myelin water imaging (MWI) in chemotherapy-related cognitive impairments (CRCI) compared to conventional DTI. Approach: Evaluate MWI changes in relation to CRCI on longitudinal brain MRI and neuropsychiatric assessments in a AYAC case-control cohort undergoing chemotherapy. GRASE-derived myelin water fraction (MWF) maps were used to create the first Southeast Asian MWF atlas, highlighting regional MWF variability in patients, and compared to FA from DTI. Results: Our MWI atlas was comparable to publicly available atlases. MWF and FA showed significant reduction in non-overlapping ROIs in AYAC patients post-chemotherapy. Impact: Myelin water fraction is a complementary quantitative marker to fractional anisotropy, detecting white matter dysmyelination in post-chemotherapy adolescent and young adult cancer patients.
Authors
- Ling Ling Chan (ORCID: https://orcid.org/0000-0001-7603-7334)
- Chia Jie Tan (ORCID: https://orcid.org/0000-0003-2452-0556)
- Mohamad Farid Bin Harunal Rashid
- Eu Jin Lim (ORCID: https://orcid.org/0009-0006-4779-6896)
- Weiling Lee (ORCID: https://orcid.org/0009-0003-4680-272X)
- Alexandre Chan (ORCID: https://orcid.org/0000-0003-4391-4219)
- Pik Hsien Chai
- Septian Hartono (ORCID: https://orcid.org/0000-0002-2411-442X)
- C. Goh
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0627
- Primary Topic
- Cancer-related cognitive impairment studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00