Multimodal MRI Reveals Neurobiological Alterations in High Schizotypy: Insights from Diffusion and Perfusion Imaging
Motivation: The etiology of schizophrenia still remains unclear that makes it harder to predict its progression. Goal(s): This study aims to highlight early neurobiological markers associated with schizophrenia. Approach: This study employed diffusion and perfusion weighted imaging to identify the structural and functional brain changes in high schizotypy population, individuals with subclinical manifestations of schizophrenia. Results: Diffusion weighted imaging reveals significant white matter abnormalities specifically in right hemisphere. Perfusion imaging shows prolonged arterial transit time and reduced cerebral blood flow in few brain regions. Impact: Our findings suggest early potential biomarkers of schizophrenia through multi-modal MRI, which is critical for early diagnosis and intervention strategies in high-risk populations.
Authors
- Wei Mao
- Rui Xue (ORCID: https://orcid.org/0000-0002-5710-0091)
- Lixian Wang (ORCID: https://orcid.org/0000-0002-1852-7308)
- Fangrong Zong (ORCID: https://orcid.org/0000-0002-2299-2069)
- Zhanhua Wei (ORCID: https://orcid.org/0000-0003-2687-0293)
- Simon Fristed Eskildsen (ORCID: https://orcid.org/0000-0003-4242-9158)
- Yihang Huang (ORCID: https://orcid.org/0000-0003-4979-3999)
- Hui‐xin Hu
- Lingling Wang (ORCID: https://orcid.org/0000-0003-4067-1995)
- Xuan Wang (ORCID: https://orcid.org/0009-0008-3242-5843)
- Yi Wang (ORCID: https://orcid.org/0000-0001-8534-6868)
- Yi Wang (ORCID: https://orcid.org/0000-0003-1567-3358)
- Raymond Chan (ORCID: https://orcid.org/0000-0001-7571-6933)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4099
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00