Feasibility of Multi-Site Structural and Functional Pulmonary MRI in Non-Sedated Infants Born Extremely Preterm
Motivation: Ultrashort echo time (UTE) and Phase-resolved functional lung (PREFUL) MRI hold promise for pulmonary structure, ventilation, and perfusion evaluation in preterm infants but have not been evaluated across multiple sites. Goal(s): To demonstrate UTE/PREFUL MRI feasibility across multiple sites in extremely preterm infants, without need for exogenous contrast agents or sedation. Approach: Across four sites, infants born <29 weeks gestation were scanned with UTE and PREFUL MRI at corrected gestational ages of 36-44 weeks. UTE score, ventilation and perfusion defect percent (VDP and QDP) were evaluated. Results: 25 participants were recruited and scanned. Elevated UTE scores, VDP, and QDP were observed. Impact: Across multiple sites, UTE and PREFUL MRI is feasible in non-sedated infants born <29 weeks and sensitive to structural, ventilation, and perfusion abnormalities in this population.
Authors
- Filip Klimeš (ORCID: https://orcid.org/0000-0003-2715-0757)
- Sherri L. Katz (ORCID: https://orcid.org/0000-0003-1879-1990)
- Thuy Mai Luu (ORCID: https://orcid.org/0000-0003-2222-186X)
- Nishard Abdeen (ORCID: https://orcid.org/0000-0002-6640-736X)
- Theo J. Moraes (ORCID: https://orcid.org/0000-0001-9968-6601)
- Andreas Voskrebenzev (ORCID: https://orcid.org/0000-0001-5699-1841)
- Brandon Zanette (ORCID: https://orcid.org/0000-0001-5645-0180)
- Mary‐Louise C. Greer (ORCID: https://orcid.org/0000-0001-6159-5472)
- Larry C. Lands (ORCID: https://orcid.org/0000-0003-2478-4412)
- Ailish Coblentz (ORCID: https://orcid.org/0000-0002-4073-5939)
- Giles Santyr (ORCID: https://orcid.org/0000-0001-7396-188X)
- Gabriel Altit (ORCID: https://orcid.org/0000-0001-5141-0964)
- Jens Vogel‐Claussen (ORCID: https://orcid.org/0000-0001-5595-6948)
- Sylvain Deschênes
- Zonah Khumalo
- Adel Mohamed
- Roya Shamsi
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0545
- Primary Topic
- Atomic and Subatomic Physics Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00