Effect of Low-Level Light Therapy on brain metabolite in Patients with Moderate Traumatic Brain Injury
Motivation: Transcranial low-level near-infrared (NIR) light therapy (LLLT) has been emerging as a therapeutic intervention for traumatic brain injury (TBI). Goal(s): The goal of this study was to assess the metabolic responses to the administration of LLLT in patients with moderate TBI. Approach: We used serial 2D MR spectroscopic imaging to measure metabolite concentrations in TBI participants who were either treated with LLLT or with sham. Results: Sham-treated participants showed a significant increase in myo-inositol/N-acetyl aspartate (mI/NAA) in the corpus callosum 3 months post injury indicating lasting inflammation and neuronal injury, while LLLT treated participants' mI/NAA ratios remained unchanged. Impact: This longitudinal study suggests a neuroprotective effect of acute administration of LLLT using MRS on individuals with moderate TBI.
Authors
- Michael R. Hamblin (ORCID: https://orcid.org/0000-0001-6431-4605)
- Suk‐Tak Chan (ORCID: https://orcid.org/0000-0001-6627-3173)
- Blair A. Parry (ORCID: https://orcid.org/0000-0002-6230-5286)
- Ramon Diaz‐Arrastia (ORCID: https://orcid.org/0000-0001-6051-3594)
- Arman Avesta (ORCID: https://orcid.org/0000-0002-6847-9818)
- Michael H. Lev (ORCID: https://orcid.org/0000-0003-0236-7319)
- Terry M. Rauch
- Michael Wenke (ORCID: https://orcid.org/0000-0002-2491-2296)
- Jarone Lee (ORCID: https://orcid.org/0000-0002-4532-8523)
- Jonathan Welt (ORCID: https://orcid.org/0009-0008-5642-5020)
- Benjamin J. Vakoc (ORCID: https://orcid.org/0000-0002-6623-3515)
- Eva‐Maria Ratai (ORCID: https://orcid.org/0000-0001-9476-6207)
- Nathaniel D. Mercaldo (ORCID: https://orcid.org/0000-0003-1658-6598)
- Rajiv Gupta (ORCID: https://orcid.org/0000-0002-5882-960X)
- Richard R. Anderson
- Lynn A. Drake
- Maria Figueiro-Longo
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0686
- Primary Topic
- Biochemical effects in animals
- Type
- article
- Field-Weighted Citation Impact
- 0.00