Fatty acid composition MRI at 1.5T identifies novel epicardial adipose tissue biomarkers of impaired myocardial perfusion in women with ANOCA
Motivation: Epicardial adipose tissue (EAT) plays a key role in metabolic inflammation affecting cardiovascular health. Identifying biomarkers of proinflammatory EAT could enhance understanding of impaired microvascular function in women with angina but no obstructive coronary artery disease (ANOCA). Goal(s): This study aims to evaluate EAT fatty acid composition (FAC) and its relationship to myocardial perfusion reserve (MPR) in female ANOCA patients. Approach: Correlations were assessed between MPR and EAT fatty acid fractions quantified using our novel MRI method. Results: Results showed MPR correlates positively with polyunsaturated fatty acids, and negatively with saturated fatty acids, suggesting FAC as a biomarker of proinflammatory EAT. Impact: This study introduces EAT FAC imaging at 1.5T as a potential mechanism of microvascular dysfunction to further investigate in women with ANOCA.
Authors
- Bishow Paudel (ORCID: https://orcid.org/0000-0003-3381-3529)
- Amit R. Patel (ORCID: https://orcid.org/0000-0001-7621-6463)
- Frederick H. Epstein (ORCID: https://orcid.org/0000-0002-1954-1988)
- Nisha Hosadurg (ORCID: https://orcid.org/0000-0001-8669-3132)
- Patricia Rodriguez Lozano
- John T. Echols (ORCID: https://orcid.org/0000-0001-7485-4912)
- Shuo Wang (ORCID: https://orcid.org/0000-0003-4919-5390)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/1025
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 0.00