Relaxation-selective IVIM imaging of Microvascular Perfusion and Fluid Compartments in the Human Choroid Plexus

Motivation: Non-invasive assessment of choroid plexus (ChP) perfusion and fluid compartments is important to assess the production of cerebrospinal fluid and waste clearance. Goal(s): To develop a relaxation selective intravoxel incoherent motion (IVIM) technique to assess the capillary perfusion and fluids compartments within the ChP. Approach: IVIM imaging with T1 and T2 selection. Results: Conventional IVIM imaging showed three fluids compartments in the ChP, corresponding to tissue, CSF, and capillary blood. FLAIR-IVIM revealed an interstitial fluids (ISF) compartment. Further study showed older adults had increased ChP volume, reduced microvascular perfusion, and decreased ISF volume compared to young adults. Impact: This study demonstrates a novel IVIM approach with T1 and T2 selection. It can assess the ChP structure and perfusion, which can potentially be used to evaluate age-related changes in its fluid compartments, such as microvascular perfusion and ISF volume.