Choroid Plexus Enlargement Mediates Cognitive Decline in Traumatic Brain Injury: UK Biobank Study

Motivation: Traumatic brain injury(TBI) is a major cause of dementia, however neuroimaging biomarkers remain underinvestigated. Although choroid plexus volume(CPV) is promising, its relationship with TBI is unclear. Goal(s): This study aims to elucidate changes in CPV in TBI patients and its relationship with cognitive function. Approach: We analyzed UK Biobank data, comparing CPV, total gray matter volume(GMV), and white matter volume(WMV) between 991 TBI-experienced individuals and 991 controls, also using mediation analysis. Results: Increased CPV and decreased GMV were found in TBI patients. CPV significantly mediated TBI's impact on cognitive function, while GMV and WMV did not show significant effects. Impact: Our findings suggest that choroid plexus volume could be a sensitive biomarker for TBI-related cognitive decline. This may contribute to developing novel therapeutic strategies targeting the choroid plexus and enable better prediction for TBI-related cognitive dysfunction.