Study on gender difference in left ventricular myocardial fibrosis in hypertrophic cardiomyopathy based on T1 mapping technology

Motivation: To clarify the impact of gender on the symptomatic phenotype of hypertrophic cardiomyopathy,thereby filling the gaps and providing clinical research data. Goal(s): To quantitatively discuss whether myocardial fibrosis symptoms and phenotypes differ by gender in patients with hypertrophic cardiomyopathy (HCM) using 3.0T cardiac magnetic resonance (CMR) T1 mapping technology. Approach: Using T1 mapping in combination with cine and myocardial late gadolinium enhancement(LGE) sequences to quantitatively analyze whether there are gender differences in symptoms and phenotypes of myocardial fibrosis in patients with HCM. Results: Female patients exhibit higher levels of myocardial fibrosis and are at an increased risk of major adverse cardiac events. Impact: Previous research on gender differences often treated gender as an incidental finding and supplementary result,lacking specialized clinical studies to analyze phenotypic differences caused by gender.T1 mapping can identify myocardial fibrosis differences that traditional LGE cannot detect, demonstrating broad application prospects.