3D amplified MRI (aMRI) and Dynamic Mode Decomposition (DMD) analysis of ICP-driven cranio-spinal motion
Motivation: Alterations in intracranial pressure (ICP) affect brain dynamics, with potential implications in idiopathic intracranial hypertension (IIH). Goal(s): To develop a dynamical analysis method that can help visualize differences in intracranial and intraspinal pulsatility following lumbar puncture. Approach: Dominant modal frequency and associated spatial patterns from dynamic mode decomposition were investigated based on amplified MR images of brain and spine, acquired pre- and post-lumbar puncture from IIH patients. Results: Following lumbar puncture, shifts in dominant modes and spatial patterns of in the cranio-spinal region were observed, with a trend of increased spinal cord motion. Impact: This study provides preliminary insights into how ICP change influenced cranio-spinal pulsatility. Spatiotemporal analysis methods have the potential to enhance patient care and support the continued development of advanced MRI techniques for clinical application.
Authors
- Vickie Shim (ORCID: https://orcid.org/0000-0002-1680-4287)
- Samantha J. Holdsworth (ORCID: https://orcid.org/0000-0002-2929-1169)
- Graham Wilson (ORCID: https://orcid.org/0000-0003-2664-1634)
- Mehmet Kurt (ORCID: https://orcid.org/0000-0001-9389-8312)
- Gonzalo D. Maso Talou (ORCID: https://orcid.org/0000-0002-5208-992X)
- Miriam Scadeng (ORCID: https://orcid.org/0000-0002-9593-2956)
- Joonsung Lee (ORCID: https://orcid.org/0000-0002-0164-1139)
- Itamar Terem (ORCID: https://orcid.org/0000-0002-6544-9138)
- Paul Condron (ORCID: https://orcid.org/0000-0002-5427-0634)
- Soroush Safaei (ORCID: https://orcid.org/0000-0001-5734-243X)
- Leigh Ellen Potter (ORCID: https://orcid.org/0000-0003-3747-1335)
- Alireza Sharifzadeh-Kermani (ORCID: https://orcid.org/0000-0001-6795-0287)
- Sarah‐Jane Guild (ORCID: https://orcid.org/0000-0002-0261-7907)
- Helen V. Danesh‐Meyer (ORCID: https://orcid.org/0000-0002-9177-003X)
- Eryn Kwon (ORCID: https://orcid.org/0000-0003-4099-0080)
- David J. Dubowitz
- Daniel Cornfeld
- Taylor Emsden
- Haribalan Kumar (ORCID: https://orcid.org/0000-0001-8729-3472)
- Matthew McDonald (ORCID: https://orcid.org/0000-0002-3024-6111)
- David Freschini
- J. T. M. Wright
- Saralyn Mackenzie
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4156
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00