Non-dilated Left Ventricular Cardiomyopathy: Non-ischemic Myocardial Scar as Predictor of Adverse Cardiovascular Events

Motivation: Management of patients with non-ischemic scar/left ventricular (LV) dysfunction in the setting of normal LV volumes is a clinical conundrum due to the lack of data on guiding their management and advice. Goal(s): This study sought to investigate the association between non-ischemic myocardial scar and long-term outcomes in patients with non-dilated left ventricular cardiomyopathy (NDLVC). Approach: 386 patients diagnosed as NDLVC by cardiac magnetic resonance were retrospectively recruited in this study. Results: Overall, in patients with NDLVC, the detection of LGE, notably when it exceeds 4% of the LV mass, was associated with an increased risk of both mechanical and electrical anomalies. Impact: A larger population with longer follow-up is warranted to confirm this finding and explore optimal treatment decisions according to different risk stratification.