Restoring Motor and Cognitive Functions with Dentate Nucleus DBS through Enhancing Brain Functional Connectivity in PTI-Induced Stroke Model

Motivation: Stroke often leads to persistent motor and cognitive impairments, with limited options for effective rehabilitation. Goal(s): To evaluate the efficacy of dentate nucleus deep brain stimulation (DN DBS) in enhancing functional recovery in a PTI-induced stroke mouse model. Approach: MR-compatible neural probes were used to perform DN DBS. Therapeutic outcomes were assessed through behavioral tests for motor and cognitive function, along with functional MR imaging. Results: DN DBS significantly improved motor and cognitive abilities in the PTI stroke model, as confirmed by behavioral metrics and neuroimaging markers. Impact: This study highlights DN DBS as a potential therapeutic intervention for post-stroke rehabilitation, bridging preclinical insights to clinical applications for improved patient outcomes.