Are we ready for 23Na MRI-based functional mapping with a 14 Tesla scanner?

Motivation: We need to develop novel methods to map brain function that go beyond traditional hemodynamic-based fMRI techniques Goal(s): To map the local field potential in the scale of tens of millisecond with 23Na-based fMRI, as well as sodium-based cerebral blood volume fMRI. Approach: We use reshuffled k-t space FLASH method for 23Na-MRI with 10 ms/frame sampling rate. Implantable RF coils with dual oscillating mode enable high SNR for 23Na-response(NaR)-MRI and SOdium-Based(SOBA)-fMRI. Results: We detected ultra-fast negative NaR signals near activated somatonsesory cortex and positive SOBA fMRI signals as surrogate control of the SNR. Impact: We investigate the feasibility of 14T rodent 23Na MRI for brain functional mapping with 10ms/frame sampling rate and a voxel size of 0.24-0.35μl.