The choroid plexus volume’s mediating effect on metabolic syndrome and cognitive performance: a prospective cohort study
Motivation: To explore changes in the choroid plexus (CP) volume in metabolic syndrome (Mets) and how these changes correlate with cognitive performance. Goal(s): This study aimed to investigate the specific components of Mets that exert the greatest influence on CP volume changes and whether they affect cognition performance. Approach: Mets patients and healthy controls were compared using TIWI and diffusion tensor imaging, and with multiple cognitive tests. Changes in the CP volume were recorded. Results: Our findings showed that the CP volume mediates the relationship between high-density lipoprotein and multiple cognitive tests. Impact: The elevated choroid plexus volume in Mets may be a neuroimaging indicator associated with cognitive impairment. Mets risk factors significantly affect the choroid plexus volume, and these volume changes are negatively correlated with cognitive performance.
Authors
- Lingfei Guo (ORCID: https://orcid.org/0000-0002-4885-625X)
- Yiwen Chen (ORCID: https://orcid.org/0009-0007-9411-0145)
- Zhenyu Cheng (ORCID: https://orcid.org/0009-0000-0717-3228)
- Changhu Liang (ORCID: https://orcid.org/0000-0003-3796-2978)
- Fushuai Zhang (ORCID: https://orcid.org/0009-0009-5833-4285)
- Xinyue Zhang (ORCID: https://orcid.org/0000-0001-6503-2378)
- Yuanyuan Wang (ORCID: https://orcid.org/0000-0003-4987-3892)
- Meng Li (ORCID: https://orcid.org/0000-0001-6631-0819)
- Na Wang (ORCID: https://orcid.org/0000-0002-9776-7683)
- Pengcheng Liang (ORCID: https://orcid.org/0009-0007-7392-2566)
- Jiaxiang Xin
- Xinying Huo
- Boyao Chen (ORCID: https://orcid.org/0009-0004-6089-7160)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/3604
- Primary Topic
- Cardiovascular Disease and Adiposity
- Type
- article
- Field-Weighted Citation Impact
- 0.00