The Functional Connectivity Changes of Default-Mode Network in Monkeys after Acute Stress Exposure

Motivation: How stress results in alterations to the resting-state functional connectivity (FC) profiles is not fully addressed. Goal(s): This study was to investigate whether stress-induced alterations in the default mode network (DMN), as observed in humans, could be replicated in adult female monkeys. Approach: The resting state functional MRI (rsfMRI) data of 18 female monkeys before and after acute stress (relocation and social isolation) were acquired and analyzed. Results: Significantly increased FC between the anterior cingulate cortex (ACC) and posterior cingulate cortex (PCC) following acute stress were seen. Impact: Monkeys could replicate the FC alteration in humans after stress and provide a unique platform for preclinical stress-related disorders.