High Resolution Diffusion MRI Tractography in the in-vivo & ex-vivo NHP brain using a human 10.5T scanner
Motivation: High-resolution diffusion MRI (dMRI) at ultra-high field is challenging due to a shorter T2 and increased susceptibility-induced distortions. Goal(s): To demonstrate the feasibility of high-resolution in-vivo and ex-vivo dMRI, and tractography using the 10.5T whole-body human scanner at CMRR-Minnesota. Approach: We explored acquisition and processing approaches for pushing resolution towards the mesoscale in the non-human primate (macaque) brain, based on pulsed-gradient spin-echo (in-vivo) and diffusion-weighted steady-state free-precession (ex-vivo). Results: We showcase high-resolution dMRI datasets (0.75 mm in-vivo, 0.4 mm ex-vivo) of the macaque brain at 10.5T and we propose a pipeline from image reconstruction to biophysical modelling that enables high-resolution tractography reconstructions. Impact: We showcase for the first time the performance of the 10.5T human whole-body MRI scanner at the CMRR, University of Minnesota, for high-resolution diffusion MRI and tractography in the in-vivo and ex-vivo macaque brain.
Authors
- Gregor Adriany (ORCID: https://orcid.org/0000-0002-6428-9005)
- Jan Zimmermann (ORCID: https://orcid.org/0000-0003-3345-6074)
- Noam Harel (ORCID: https://orcid.org/0000-0002-6034-3801)
- Matt Waks (ORCID: https://orcid.org/0000-0003-1743-8888)
- Mohamed Kotb Selim (ORCID: https://orcid.org/0000-0001-8610-3147)
- Hamza Farooq (ORCID: https://orcid.org/0000-0001-5311-4368)
- Pramod Kumar Pisharady (ORCID: https://orcid.org/0000-0002-0756-1199)
- Essa Yacoub (ORCID: https://orcid.org/0009-0000-1007-9056)
- Saâd Jbabdi (ORCID: https://orcid.org/0000-0003-3234-5639)
- Shaun Warrington (ORCID: https://orcid.org/0000-0002-7198-8162)
- Stamatios N. Sotiropoulos (ORCID: https://orcid.org/0000-0003-4735-5776)
- Alexander Bratch
- Edward J. Auerbach (ORCID: https://orcid.org/0000-0003-4553-1545)
- Kâmil Uǧurbil (ORCID: https://orcid.org/0000-0002-8475-9334)
- Sarah R. Heilbronner (ORCID: https://orcid.org/0000-0003-0893-5364)
- Steve Jungst (ORCID: https://orcid.org/0000-0001-8374-7924)
- Christophe Lenglet (ORCID: https://orcid.org/0000-0003-4646-3185)
- Steen Moeller (ORCID: https://orcid.org/0000-0003-1698-7260)
- Benjamin C. Tendler (ORCID: https://orcid.org/0000-0003-2095-8665)
- Karla L. Miller (ORCID: https://orcid.org/0000-0002-2511-3189)
- Wenchuan Wu (ORCID: https://orcid.org/0000-0002-5020-5165)
- Franco Pestilli
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0322
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00