The relationship between sleep disorder,neuroinflammation,glymphatic dysfunction, and cognition: a study based on Parkinson’s disease continuum participants

Motivation: To explore the potential factors of cognitive decline in patients with Parkinson's disease (PD). Goal(s): Whether glymphatic makers mediate the relationship between sleep distorder/neuroinflammation and cognitive performance in PD patients. Approach: Statistical methods used partial correlation analysis and mediation analysis. Results: Glymphatic markers as a significant mediator between sleep disorder/ neuroinflammation between cognitive performanceon on PD participants. Impact: Our study provided evidence that both sleep disorder and neuroinflammation were associated with glymphatic dysfunction, which is further related to cognitive impairment. These results may provide a theoretical basis for new targets for treating PD.