VO-CEST: Variable-Optimized CEST using optimized adiabatic RF design on 3T

Motivation: To reduce the possible oscillation artifacts and improve saturation uniformity using adiabatic saturation pulse in CEST imaging. Goal(s): This study is dedicated to improve the imaging quality and mapping accuracy when saturating under adiabatic pulse. Approach: A variable optimization of adiabatic factor for any shape of adiabatic Spin-Lock pulse with respect to frequency offset is proposed. Results: Oscillation artifact is fairly reduced, saturation is more uniform and mapping result is improved through better insensitivity to field inhomogeneity. Impact: A novel protocol that focusing on optimizing the RF waveform and bandwidth is proposed and can be broadly used in tasks involving adiabatic pulses.