Personalized brain tumor radiation therapy planning pipeline based on spectroscopic MRI using the Brain Imaging Collaboration Suite (BrICS)

Motivation: Current spectroscopic MRI (sMRI) workflows are challenging to integrate into clinical practice due to data size, processing complexity, and computational demands. An efficient sMRI pipeline could enhance brain tumor treatment planning, enabling personalized and data-driven therapeutic decisions. Goal(s): To develop and validate PyMIDAS, a Python-based pipeline that improves the efficiency and accessibility of sMRI for brain tumor imaging, facilitating clinical workflow integration. Approach: PyMIDAS was created by porting MIDAS (current solution) from IDL to Python, optimized with distributed processing and GPU computing. Validation included SSIM and cross-correlation comparisons across multi-site datasets. Results: PyMIDAS demonstrated similar output to MIDAS while meeting validation criteria. Impact: PyMIDAS, a Python version of the existing IDL-based pipeline, accelerates and simplifies spectroscopic MRI-based brain tumor treatment planning, enabling clinical workflow integration. Its improved computational efficiency and flexibility support broader adoption of advanced spectroscopic MRI for brain tumor imaging.