The comprehensive Subcortical Atlas of the Human Brain (“SAHB”) derived from high-resolution multimodal MRI at 7T.

Motivation: To develop a detailed 3D atlas to help locate the subcortical subregions for anatomical, functional, and clinical studies. Goal(s): To generate the comprehensive subcortical atlas of the human brain, using multimodal MRI ex vivo at 7T, and register it to an in vivo MNI template for 3D segmentation. Approach: Obtained high-resolution images from the fixed brainstem at 7T using MAP-MRI with 250 μm resolution. Results: MAP-MRI enabled detailed noninvasive segmentation of deep brain structures at a high spatial resolution. Impact: Tracing and validating subcortical regions in 3D are imperative for neurosurgical planning for DBS, fMRI studies, cross-species comparison, and establishing brain structure-function relationships.