Neurofluid and Microstructural Evaluation by Time-Dependent Diffusion Analysis and White Matter Parameters in Obstructive Sleep Apnea
Motivation: Evaluating neurofluid dynamics, crucial for brain clearance, requires a comprehensive approach utilizing multiple assessment methods. We explore the role of time-dependent diffusion imaging in this context. Goal(s): This study examines obstructive sleep apnea, potentially impacting neurofluid dynamics, to assess correlations between time-dependent diffusion parameters and markers of sleep and respiration. Approach: In 42 patients, we analyzed correlations between polysomnography-derived indicators and ΔADC (ADCOGSE - ADCPGSE) in deep white matter. Results: ΔADC correlated well with respiratory parameters, while correlations with sleep markers were limited. Impact: ΔADC could serve as an indicator of brain microstructural changes linked to respiratory function, with implications for evaluating neurofluid dynamics.
Authors
- Toshiki Nakane (ORCID: https://orcid.org/0000-0002-0383-2879)
- Shinji Naganawa
- Nobuyasu Ichinose (ORCID: https://orcid.org/0000-0001-6580-5086)
- Rei Nakamichi (ORCID: https://orcid.org/0000-0001-6933-0954)
- Toshiaki Taoka (ORCID: https://orcid.org/0000-0001-9227-0240)
- Rintaro Ito (ORCID: https://orcid.org/0000-0002-7971-043X)
- Seiko Miyata (ORCID: https://orcid.org/0000-0002-1144-5676)
- Hiroshige Fujishiro (ORCID: https://orcid.org/0000-0001-9822-5432)
- Kunihiro Iwamoto (ORCID: https://orcid.org/0000-0003-3868-3372)
- Masashi Ikeda (ORCID: https://orcid.org/0000-0001-6237-2449)
- Kazushige Ichikawa
- Akifumi Kamiunten
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/5073
- Primary Topic
- Obstructive Sleep Apnea Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00