Open-Source Implementation for X-Nuclear and Multi-Site Sequences within the Pulseq Framework
Motivation: Support X-nuclear and vendor-neutral acquisitions for sharing and scanning across scanners and sites. Goal(s): Build a GE interpreter for X-nuclear acquisition using Pulseq framework; create a modular sequence that can support fast and flexible X-nuclear acquisition. Approach: X-nuclei capabilities were built into TOPPE GE interpreter. A modular 2D GRE spiral sequence was developed, integrating a flexible RF and readout module, and evaluated by both phantom and in-vivo studies. Results: Data from 31P, 2H, and 13C phantoms, multi-site 13C phantom, 2H-MRS brain volunteer, and hyperpolarized [1-13C]pyruvate animal studies demonstrated the feasibility, flexibility and reproducibility of the TOPPE MNS GE interpreter and modular spiral sequence. Impact: X-nuclear sequence developers can now more easily transfer their sequences across vendors and software for multi-site studies.
Authors
- Zhen Wang (ORCID: https://orcid.org/0000-0002-5765-0827)
- Jon‐Fredrik Nielsen (ORCID: https://orcid.org/0000-0002-2058-3579)
- Robert Schulte (ORCID: https://orcid.org/0000-0001-7882-3507)
- Duan Xu (ORCID: https://orcid.org/0000-0003-0550-4235)
- Daniel B. Vigneron (ORCID: https://orcid.org/0000-0001-5795-8699)
- Peder E. Z. Larson (ORCID: https://orcid.org/0000-0003-4183-3634)
- Jeremy W. Gordon (ORCID: https://orcid.org/0000-0003-2760-4886)
- Dirk Mayer (ORCID: https://orcid.org/0000-0001-7557-9019)
- Andreas Korzowski (ORCID: https://orcid.org/0000-0002-0244-9712)
- Robert R. Flavell (ORCID: https://orcid.org/0000-0002-8694-1199)
- Changhua Mu (ORCID: https://orcid.org/0000-0002-5007-0133)
- Xiaoxi Liu (ORCID: https://orcid.org/0000-0003-0657-8922)
- Di Cui
- Lucas Carvajal
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/1273
- Primary Topic
- Particle physics theoretical and experimental studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00