Efficient 5D Motion Resolved Imaging: Assessing Spatial Resolutions for Faster Acquisition Without Compromising LV Ejection Fraction Accuracy

Motivation: Accurate LVEF assessment is essential for evaluating cardiac function, but conventional cardiac MRI techniques are time-consuming, operator-dependent, and have suboptimal anisotropic spatial resolution. Goal(s): To determine if accurate LVEF measurements can be achieved with shorter acquisition times and reduced spatial resolution by leveraging a 5D free-running framework with inter-bin motion compensation (FRF-MC). Approach: FRF-MC was optimized and compared to the original 5D method at three spatial resolutions and against a reference 2D cine in 9 healthy participants. Results: FRF-MC maintained accurate LVEF measurements across all investigated spatial resolutions with superior image quality, enabling rapid, free-breathing MRI acquisitions in as little as 2.5 minutes. Impact: Leveraging inter-bin motion compensation in the free-running framework with lower spatial resolution enables rapid, high-quality, free-breathing cardiac MRI in under 2.5 minutes without compromising left ventricular ejection fraction measurement accuracy. This advancement may enhance clinical workflows and improve patient comfort.