Vendor-Neutral, Free-Breathing Fat Quantification Demonstrates Low Bias and High Reproducibility Across Centers at 0.55T, 1.5T, and 3T
Motivation: Flip-angle modulation (FAM) for motion-robust fat quantification was previously implemented in the vendor-neutral platform Pulseq and demonstrated in two vendors at 3T only. Validation of FAM in additional vendors and field strengths is needed. Goal(s): Benchmark the quantitative bias and reproducibility of Pulseq-FAM across sites, systems, vendors, and field strengths, relative to product 3D-CSE and vendor-platform FAM. Approach: Phantom study at four sites with three vendors at 0.55T, 1.5T, and 3T; in vivo free-breathing feasibility evaluated where possible. Results: Pulseq-FAM shows low bias and similar or improved reproducibility compared to 3D-CSE, and free-breathing feasibility in all field strengths and vendors. Impact: The strong performance of Pulseq-FAM may enable broader access to free-breathing fat quantification in more vendors and systems. Pulseq-FAM may be used in future studies, such as multi-center clinical trials, which desire harmonization of sequences.
Authors
- Jon‐Fredrik Nielsen (ORCID: https://orcid.org/0000-0002-2058-3579)
- David R. Rutkowski (ORCID: https://orcid.org/0000-0002-1168-5004)
- Sook Wah Yee (ORCID: https://orcid.org/0000-0001-8121-8746)
- William A. Grissom (ORCID: https://orcid.org/0000-0002-3289-1827)
- Diego Hernando (ORCID: https://orcid.org/0000-0002-0016-0317)
- Yogesh Rathi (ORCID: https://orcid.org/0000-0002-9946-2314)
- Jean H. Brittain (ORCID: https://orcid.org/0000-0002-1314-8114)
- Jiayi Tang (ORCID: https://orcid.org/0009-0007-7590-875X)
- Maxim Zaitsev (ORCID: https://orcid.org/0000-0001-7530-1228)
- Shohei Fujita (ORCID: https://orcid.org/0000-0003-4276-6226)
- Scott B. Reeder (ORCID: https://orcid.org/0000-0003-4728-8171)
- Daiki Tamada (ORCID: https://orcid.org/0000-0003-3615-459X)
- Eugene Milshteyn (ORCID: https://orcid.org/0000-0003-0213-7003)
- Berkin Bilgic̦ (ORCID: https://orcid.org/0000-0002-9080-7865)
- Imam Ahmed Shaik (ORCID: https://orcid.org/0009-0000-2849-8849)
- Yun Jiang (ORCID: https://orcid.org/0000-0002-0713-9641)
- Pengcheng Xu (ORCID: https://orcid.org/0000-0001-8596-9555)
- Christopher Keen
- Andrew Ellison (ORCID: https://orcid.org/0009-0008-2056-7182)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4594
- Citations
- 1
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.16