Quantification of Total White Matter Perivascular Space Volume: Follow-up in Dutch-type Cerebral Amyloid Angiopathy
Motivation: Most commonly used methods to assess enlarged perivascular spaces (PVS) are visual rating scales that exhibit a strong ceiling effect and are limited to a single slice, limiting the assessment of progression. Goal(s): To develop and apply a method to quantitatively assess whole-brain PVS in Dutch-type Cerebral Amyloid Angiopathy (D-CAA). Approach: We applied a semi-automatic method with an in-house developed tool to assess whole-brain PVS volume fraction (PVSvf) over four-year follow-up. Results: Significant baseline differences were observed. No group differences were seen between symptomatic, pre-symptomatic D-CAA and controls in PVSvf over four years of follow-up. Impact: Sensitive measurement of PVS-enlargement will increase our understanding of disease mechanisms and allow monitoring of disease progression. This is relevant for developing treatment strategies and especially for tracking the effectiveness of treatments.
Authors
- Ingeborg Rasing (ORCID: https://orcid.org/0000-0002-0953-7133)
- Mark A. van Buchem (ORCID: https://orcid.org/0000-0003-1881-1998)
- M. Schipper (ORCID: https://orcid.org/0000-0003-1463-0997)
- Emma A. Koemans (ORCID: https://orcid.org/0000-0003-0560-8077)
- Sabine Voigt (ORCID: https://orcid.org/0000-0002-5182-6676)
- Thijs W. van Harten (ORCID: https://orcid.org/0000-0002-3408-9379)
- Kanishk Kaushik (ORCID: https://orcid.org/0000-0003-1429-6853)
- Erik W. van Zwet (ORCID: https://orcid.org/0000-0001-5537-3179)
- Jeroen van der Grond (ORCID: https://orcid.org/0000-0002-0185-3158)
- Marieke J.H. Wermer (ORCID: https://orcid.org/0000-0002-6838-9521)
- Matthias J.P. van Osch (ORCID: https://orcid.org/0000-0001-7034-8959)
- Sanneke van Rooden (ORCID: https://orcid.org/0000-0002-1468-8403)
- Lydiane Hirschler (ORCID: https://orcid.org/0000-0003-2379-0861)
- Rosemarie van Dort (ORCID: https://orcid.org/0000-0002-7777-3189)
- Marianne van Walderveen
- Arie-Tjerk Razoux-Schultz
- Steven Greenberg
- Sanne Schriemer
- Reinier van der Zwet
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/5039
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00