129Xe red blood cell chemical shift and T2* in patients hospitalised due to COVID-19 with and without residual lung abnormalities seen on CT
Motivation: Previous studies show red blood cell (RBC) chemical shift, RBC T2* and M T2* may be sensitive to alveolar-capillary diffusion. Goal(s): To determine whether these 129Xe MRI measures are associated with markers of clinical function in patients hospitalised due to COVID-19. Approach: Patients hospitalised due to COVID-19 with and without residual lung abnormalities (RLAs) had 6 month and 1 year MRI. RBC chemical shift, RBC T2* and M T2* were calculated from dissolved phase 129Xe MRI. Results: RBC chemical shift correlates with TLCO Z-score in patients with RLAs. RBC T2*and M T2* were significantly longer in patients with RLAs, compared to patients without. Impact: RBC chemical shift is sensitive to alveolar-capillary diffusion abnormalities in patients with residual lung abnormalities following COVID-19 and may enable more sensitive monitoring of gas transfer abnormalities in these patients.
Authors
- Jim M. Wild (ORCID: https://orcid.org/0000-0002-7246-8660)
- Amanda Goodwin (ORCID: https://orcid.org/0000-0002-1488-6549)
- James Eaden (ORCID: https://orcid.org/0000-0002-9314-7233)
- Laurie Smith (ORCID: https://orcid.org/0000-0002-5769-423X)
- Martin Brook (ORCID: https://orcid.org/0000-0002-2739-587X)
- Joseph Jacob (ORCID: https://orcid.org/0000-0002-8054-2293)
- Kevin E. Johnson (ORCID: https://orcid.org/0000-0001-8968-6974)
- Smitha Rajaram (ORCID: https://orcid.org/0000-0001-5010-2353)
- Gísli Jenkins (ORCID: https://orcid.org/0000-0002-7929-2119)
- James Meiring (ORCID: https://orcid.org/0000-0001-9183-5174)
- Paul Collini (ORCID: https://orcid.org/0000-0001-6696-6826)
- Gary Mills (ORCID: https://orcid.org/0000-0002-3929-2149)
- Iain D. Stewart (ORCID: https://orcid.org/0000-0002-1340-2688)
- James Ball (ORCID: https://orcid.org/0000-0003-4795-4007)
- Guilhem Collier (ORCID: https://orcid.org/0000-0002-1874-4775)
- Megan Plowright (ORCID: https://orcid.org/0000-0001-8849-8736)
- Galina E. Pavlovskaya (ORCID: https://orcid.org/0000-0003-4352-3269)
- Graham Norquay (ORCID: https://orcid.org/0000-0002-4108-9035)
- Kher Lik Ng (ORCID: https://orcid.org/0000-0003-4518-3085)
- Ian P. Hall (ORCID: https://orcid.org/0000-0001-9933-3216)
- Philip L. Molyneaux (ORCID: https://orcid.org/0000-0003-1301-8800)
- Neil J. Stewart (ORCID: https://orcid.org/0000-0001-8358-394X)
- Jonathan Brooke
- James Watson (ORCID: https://orcid.org/0000-0002-0423-4889)
- Fergus Gleeson (ORCID: https://orcid.org/0000-0002-5121-3917)
- James T. Grist (ORCID: https://orcid.org/0000-0001-7223-4031)
- Rod Lawson (ORCID: https://orcid.org/0000-0003-2860-8619)
- Laura Saunders (ORCID: https://orcid.org/0000-0002-1080-9861)
- Ling‐Pei Ho (ORCID: https://orcid.org/0000-0001-8319-301X)
- Lisa Watson
- Phillip Wade
- A. A. Roger Thompson (ORCID: https://orcid.org/0000-0002-0717-4551)
- Jody Bray (ORCID: https://orcid.org/0000-0003-0700-5034)
- Thomas Meersman
- Tom Newman (ORCID: https://orcid.org/0000-0002-7987-9948)
- Lotta Gustafsson (ORCID: https://orcid.org/0000-0002-9826-9133)
- Paul Hughes (ORCID: https://orcid.org/0000-0002-7979-5840)
- Alberto Biancardi (ORCID: https://orcid.org/0009-0000-2765-0773)
- Helen Marshall (ORCID: https://orcid.org/0000-0002-7425-1449)
- David Capener (ORCID: https://orcid.org/0000-0003-2394-8729)
- Arthur Harrison
- Zoë Gabriel
- Andy Swift
- Scarlett Strikland
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4635
- Primary Topic
- Atomic and Subatomic Physics Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00