Bridging the gap: 150μm resolution whole brain ex-vivo imaging at 7T with RF shimming
Motivation: To demonstrate that ultra-high resolution whole brain MRI acquired at ultra-high field (7T) can be used to acquire mesoscale voxel sizes in ex-vivo samples, using commercially available hardware. Goal(s): To evaluate the impact of RF-shimming methods on image quality in mesoscale MRI, and to acquire ex-vivo imaging with sufficient resolution and SNR to investigate mesoscale pathology. Approach: At 150μm isotropic resolution, RF shimming approaches were compared for their SNR and CoV. Subsequently, high-SNR ex-vivo scanning was achieved by averaging and denoising, and used for neuroradiological reading. Results: Ultra-high resolution MRI enabled the detection and delineation of fine lesions and mesoscale anatomical structures. Impact: Using commercial hardware and overnight scan times, ultra-high resolution MRI at 150μm isotropic voxel size can be acquired with sufficient SNR and image quality to detect and differentiate mesoscale structures
Authors
- Martin Cseh (ORCID: https://orcid.org/0000-0002-5303-0188)
- Mark Rekecki
- Kelvin Chow (ORCID: https://orcid.org/0000-0003-0698-1746)
- Gonçalo Castelo‐Branco (ORCID: https://orcid.org/0000-0003-2247-9393)
- Tobias Granberg (ORCID: https://orcid.org/0000-0001-6700-1022)
- Matthias Weigel (ORCID: https://orcid.org/0000-0002-4910-1414)
- Russell Ouellette (ORCID: https://orcid.org/0000-0001-9217-1445)
- Adrian Szum
- László Székely (ORCID: https://orcid.org/0000-0001-6144-6573)
- Daniel S. Papp (ORCID: https://orcid.org/0000-0003-1481-1413)
- Cristina Granziera (ORCID: https://orcid.org/0000-0002-4917-8761)
- Tony Jimenez-Beristain (ORCID: https://orcid.org/0009-0005-3756-3354)
- Donggyun Park
- Zsolt Geretovszky
- Hadrien van Loo
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4386
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00