Correlation Between Choroid Plexus Calcification and Motor Outcomes of Deep Brain Stimulation in Parkinson’s Disease

Motivation: The current clinical predictive factors do not reliably predict DBS outcomes. We hypothesized that the extent of the choroid plexus (ChP) calcification may serve as a potential biomarker for understanding variability in DBS results. Goal(s): To investigate the relationship between ChP calcification and post-DBS motor outcomes. Approach: T1-weighted imaging and QSM were performed in forty PD patients who underwent STN-DBS at a 3T MRI system. The relationship between ChP mean susceptibility, calcification volume, and DBS-related motor improvement was evaluated. Results: ChP calcification relative volume was negatively correlated with total motor improvement, gait stability improvement, and bradykinesia improvement. Impact: The extent of choroid plexus calcification measured by quantitative susceptibility mapping is negatively correlated with DBS outcomes, offering a potential biomarker to optimize patient-specific DBS prognosis.