Impaired Blood Brain Barrier in Parkinson’s Disease: A DCE-MRI study
Motivation: Blood-brain barrier dysfunction (BBBd) plays a role in several neurological disorders like epilepsy and Alzheimer's Disease. However, In Parkinson's Disease (PD), evidence on BBBd is limited. Goal(s): To assess the feasibility of detecting BBBd by using Dynamic-contrast enhanced (DCE)-MRI in PD patients and study its association with cognitive manifestations. Approach: DCE-MRI scans of age-matched controls and PD patients were analyzed using the extended Tofts model and a slow accumulation metric. Results: Findings indicate higher permeability and lower vascularity in PD patients compared with controls in several brain regions. Impact: This study demonstrates that DCE-MRI can detect BBB dysfunction in PD, marked by higher permeability and lower vascularity, offering insights for diagnostics, biomarker discovery, and BBB-targeted treatment development in Parkinson's disease.
Authors
- Dan Z. Milikovsky (ORCID: https://orcid.org/0000-0002-4826-5273)
- Gadi Maayan Eshed
- Rotem Iris Orad
- Tamara Shiner (ORCID: https://orcid.org/0000-0002-6368-9656)
- Dafna Ben Bashat (ORCID: https://orcid.org/0000-0001-8396-1031)
- Roy N. Alcalay (ORCID: https://orcid.org/0000-0002-5717-4875)
- Nir Giladi (ORCID: https://orcid.org/0000-0003-1482-8522)
- Noa Bregman (ORCID: https://orcid.org/0000-0003-4856-086X)
- Uri Nevo (ORCID: https://orcid.org/0000-0002-9343-6609)
- Avner Thaler (ORCID: https://orcid.org/0000-0001-7629-8120)
- Sheida Mirloo (ORCID: https://orcid.org/0000-0003-2608-9771)
- Anat Mirelman (ORCID: https://orcid.org/0000-0002-1520-2292)
- Moran Artzi (ORCID: https://orcid.org/0000-0003-4214-1875)
- Lyna Kamintsky (ORCID: https://orcid.org/0000-0001-6776-0969)
- Sapir Fajerzstein
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4549
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00