In vivo Brain B1+ Inhomogeneity Correction and NOE Image Enhancement at 7T via Flexible Metasurfaces
Motivation: NOE at 7 Tesla suffers from image degradation due to signal drop off caused by B1 inhomogeneity. Goal(s): To demonstrate in vivo on 7T MRI, brain B1+, NOEMTR, and multipool metabolite map enhancement via metasurfaces. Approach: 3D NOE images were acquired, consisting of a full Z-spectrum, which was used in conjunction with a multipool Lorentzian fitting model to generate MT, APT, amine, and rNOE pools. B1+ maps were acquired as an additional comparison metric. Results: Metasurfaces globally enhanced the transmit efficiency, particularly in the temporal lobe regions. NOEMTR and amplitude fit maps showed improved image contrast and uniformity. Impact: Metasurfaces improve metabolic NOE image quality at 7T, making this technique more suitable for investigating pathologies in the temporal lobes and cerebellum.
Authors
- Ravi Prakash Reddy Nanga (ORCID: https://orcid.org/0000-0002-3644-5656)
- Ravinder Reddy (ORCID: https://orcid.org/0000-0003-4580-2392)
- Anil Mathur (ORCID: https://orcid.org/0000-0002-2733-337X)
- Wyger M. Brink (ORCID: https://orcid.org/0000-0001-9974-7662)
- Neil Wilson (ORCID: https://orcid.org/0000-0002-5368-9855)
- John A. Detre (ORCID: https://orcid.org/0000-0002-8115-6343)
- Anshuman Swain (ORCID: https://orcid.org/0000-0002-0257-8610)
- Mark Elliott (ORCID: https://orcid.org/0000-0002-5281-7245)
- Paul Jacobs
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4398
- Primary Topic
- Photoreceptor and optogenetics research
- Type
- article
- Field-Weighted Citation Impact
- 0.00