A comparative analysis of single-echo and multi-echo EPI sequences for task-fMRI
Motivation: Multi-Echo (ME) fMRI technique during task has shown to enhance BOLD sensitivity when compared with single-echo data derived from ME itself (Echo-2). Goal(s): Investigate the perks of a ME protocol with a comprehensive comparison with an Optimized Single-Echo (OSE) acquisition (i.e. not with data derived from ME itself). Approach: We characterized 3 datasets (ME, OSE, Echo-2) computing single-subject and group-level analyses, performance metrics and fMRI reliability. Results: ME and OSE showed better results than Echo-2 confirming previous studies, but in a comparison of optimized sequences, the superior performance of ME is not confirmed. Impact: A comprehensive comparison of Multi-Echo fMRI with an Optimized Single-Echo (OSE) acquisition (i.e. not with data derived from ME itself) enables a direct evaluation of two different acquisition approaches at their best performances.
Authors
- Alice Giubergia (ORCID: https://orcid.org/0000-0002-7084-4220)
- Tommaso Ciceri (ORCID: https://orcid.org/0000-0001-5566-8110)
- Marco Castellaro (ORCID: https://orcid.org/0000-0002-1203-2670)
- Denis Peruzzo (ORCID: https://orcid.org/0000-0002-9480-379X)
- Alessandra Bertoldo (ORCID: https://orcid.org/0000-0002-6262-6354)
- Sara Mascheretti (ORCID: https://orcid.org/0000-0002-0060-3261)
- Valentina Lampis (ORCID: https://orcid.org/0000-0003-0895-7918)
- Giulio Ferrazzi (ORCID: https://orcid.org/0000-0001-7449-4718)
- Florian Montano (ORCID: https://orcid.org/0009-0004-7249-3796)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/3733
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00