Pre- and Post-operative Regional Fetal Brain Growth in Fetuses with Spina Bifida Aperta
Motivation: It is important to understand fetal brain development in fetuses impacted by spina bifida aperta to aid in prenatal planning. Goal(s): We aim to identify imaging biomarkers that can potentially aid in the decision-making process for in utero spinal lesion closure surgery and discover the impact of disease characteristics on regional fetal brain growth. Approach: Pre- and post-operative fetal brain MRIs were acquired, and regional fetal brain growth pre- and post-operatively were compared to lesion type and Chiari II hindbrain herniation level in 96 patients. Results: Relationships between the cerebellum, brainstem and eCSF volumes were found with lesion type and hindbrain herniation level. Impact: Longitudinal fetal brain MRI of spina bifida patients has the potential to expand our knowledge of fetal brain development in neural tube disorders.
Authors
- Ueli Moehrlen (ORCID: https://orcid.org/0000-0001-6418-1136)
- M. Meuli (ORCID: https://orcid.org/0009-0002-5805-8777)
- Beth Padden (ORCID: https://orcid.org/0000-0001-7585-1510)
- Patrice Grehten (ORCID: https://orcid.org/0000-0003-4920-9764)
- Nicole Ochsenbein‐Kölble (ORCID: https://orcid.org/0000-0002-7691-965X)
- Raimund Kottke (ORCID: https://orcid.org/0000-0003-0166-2770)
- Kelly Payette (ORCID: https://orcid.org/0000-0001-7041-0150)
- András Jakab (ORCID: https://orcid.org/0000-0001-6291-9889)
- Luca Mazzone (ORCID: https://orcid.org/0000-0002-4344-8441)
- Beatrice Latal (ORCID: https://orcid.org/0000-0003-1309-4790)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/3786
- Primary Topic
- Fetal and Pediatric Neurological Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00