Effect of Ayurvedic formulation on metabolic profile of posterior cingulate cortex in ageing population

Motivation: The growing elderly population has led to a rise in cognitive impairments and neurodegenerative disorders. Development of therapeutic strategies to stop and revert these changes are essential. Goal(s): To find age related changes in PCC and effect of Brahmi Ghrita on these changes in posterior cingulate cortex. Approach: 54 healthy Indians underwent brain scanning for MR spectroscopy and 8 participants have completed the intervention. Results: Total choline, myo-Inositol and total creatine found to significantly increased in elderly as compared to young and middle-aged participants. Brahmi Ghrita intervention have reduced the concentration of total choline in PCC. Impact: The study highlights age-related metabolic changes in the posterior cingulate cortex, revealing increased choline, myo-inositol, and creatine levels in the elderly. Importantly, Brahmi Ghrita shows potential in reversing these changes, suggesting a therapeutic avenue for cognitive health.