129Xe ventilation and 1H anatomical MRI after lung transplant
Motivation: More sensitive techniques are needed to detect declining lung function in patients after lung transplant. Goal(s): To assess ventilation and structural abnormalities in patients after lung transplant. Approach: 14 lung transplant recipients were assessed with 129Xe ventilation MRI, 1H structural MRI, lung clearance index (LCI) and spirometry. Results: 129Xe ventilation MRI can be used to identify ventilation defects in lung transplant patients and structural abnormalities were detected with 1H MRI in some patients. Most lung transplant patients had 129Xe MRI and LCI ventilation abnormalities even when post-transplant FEV1 was preserved. Impact: 129Xe ventilation MRI and lung clearance index could be used for more sensitive monitoring of lung function after lung transplant.
Authors
- Jim M. Wild (ORCID: https://orcid.org/0000-0002-7246-8660)
- Laurie Smith (ORCID: https://orcid.org/0000-0002-5769-423X)
- Karthik Santhanakrishnan (ORCID: https://orcid.org/0000-0002-4499-847X)
- Alex Robert Horsley (ORCID: https://orcid.org/0000-0003-1828-0058)
- Andrew J. Swift (ORCID: https://orcid.org/0000-0002-8772-409X)
- John Blaikley (ORCID: https://orcid.org/0000-0001-7651-5682)
- Neil J. Stewart (ORCID: https://orcid.org/0000-0001-8358-394X)
- Laura Saunders (ORCID: https://orcid.org/0000-0002-1080-9861)
- Madeleine Driskel (ORCID: https://orcid.org/0000-0001-5309-4678)
- Jody Bray (ORCID: https://orcid.org/0000-0003-0700-5034)
- Alberto Biancardi (ORCID: https://orcid.org/0009-0000-2765-0773)
- Helen Marshall (ORCID: https://orcid.org/0000-0002-7425-1449)
- Anna Zalewska‐Janowska (ORCID: https://orcid.org/0000-0001-9900-7680)
- David Capener (ORCID: https://orcid.org/0000-0003-2394-8729)
- Shagufta Fazal
- Ryan Munro
- Olly Rodgers
- Venkateswaran Rajamiyer
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0914
- Primary Topic
- Atomic and Subatomic Physics Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00