Multi-vendor reproducibility of joint T1-T2 transient-state relaxometry using platform-specific implementations at 3T
Motivation: Transient-state relaxometry (TSR) provides fast estimation of T1 and T2 but the variability of implementations across different vendors may compromise multi-center studies. Goal(s): To assess accuracy, repeatability and inter-vendor reproducibility of TSR T1 and T2 maps. Approach: A phantom and five volunteers were scanned at four 3T MR systems from three manufacturers. We computed coefficients-of-variation to estimate voxelwise variability and general linear model analysis to measure biases associated with sites. Results: We obtained excellent accuracy and repeatability and generally good inter-site reproducibility among the different implementations. T1 and T2 differences may be attributable to MT and B1 effects, respectively. Impact: Transient-state relaxometry represents a broadly applicable method for quantitative imaging. The assessment of inter-site reproducibility provides a preliminary indication of its sensitivity in detecting pathologies in a multi-center study.
Authors
- Rosa Pasquariello (ORCID: https://orcid.org/0000-0002-5375-6034)
- Anna Nigri (ORCID: https://orcid.org/0000-0002-1197-5458)
- Cristina Baldoli (ORCID: https://orcid.org/0000-0003-2697-5132)
- Michela Tosetti (ORCID: https://orcid.org/0000-0002-2515-7560)
- Matteo Cencini (ORCID: https://orcid.org/0000-0001-7060-6305)
- Domenico Aquino (ORCID: https://orcid.org/0000-0002-1289-9573)
- Alessandro Sbrizzi (ORCID: https://orcid.org/0000-0003-3276-4542)
- Marta Lancione (ORCID: https://orcid.org/0000-0001-8911-7878)
- Francesco Ghielmetti (ORCID: https://orcid.org/0000-0003-2183-5077)
- Oscar van der Heide (ORCID: https://orcid.org/0000-0002-8451-525X)
- S. Romano (ORCID: https://orcid.org/0000-0001-6271-2992)
- Paola Scifo (ORCID: https://orcid.org/0000-0001-5135-8086)
- Domenico Montanaro (ORCID: https://orcid.org/0000-0002-9895-7016)
- Laura Biagi (ORCID: https://orcid.org/0000-0003-2159-439X)
- Ilaria Neri (ORCID: https://orcid.org/0000-0002-0235-3454)
- Edwin Versteeg (ORCID: https://orcid.org/0000-0003-3235-3970)
- Maurizio Elia (ORCID: https://orcid.org/0000-0002-0414-1359)
- Salvatore Pettinato
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/1661
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00