Investigating the Mechanism of Inositol Against Paclitaxel Chemoresistance on TNBC by Using 7T Multiparametric MRI and Mitochondrial Changes

Motivation: Paclitaxel resistance poses a challenge in treating triple-negative breast cancer (TNBC), necessitating new strategies to enhance treatment efficacy. Goal(s): The study aims to explore whether inositol can inhibit PTX chemoresistance in TNBC by suppressing mitochondrial fission. Approach: PTX-resistant 4T1 cells were inoculated in mice, which received treatments with PTX and/or inositol. Multiparametric MRI, histopathology, and biochemical analyses were used to assess effects on mitochondrial morphology and treatment outcomes. Results: Inositol increased mitochondrial stability, reduced tumor volume, and lowered PTX resistance markers, demonstrating its potential to counteract PTX resistance in TNBC effectively. Impact: The findings suggest that inositol could become a novel therapeutic strategy for overcoming PTX resistance in TNBC, potentially guiding future research on mitochondrial-targeted treatments. This could lead to improved clinical outcomes for patients with drug-resistant breast cancer.