Measuring cerebrovascular reactivity: a comparison of Gradient-Echo and Spin-Echo BOLD with Arterial Spin Labelling

Motivation: Gradient-echo (GE) BOLD-fMRI has been used with vasodilation to measure the cerebrovascular reactivity (CVR). However, the GE-BOLD signal is weighted by cerebral blood volume (CBV) in large veins. Spin-Echo (SE) BOLD fMRI is less sensitive to large veins and may deliver estimates closer to the physiological CVR. Goal(s): To compare GE-BOLD, SE-BOLD, and CBF based CVR measurements across subjects and across space. Approach: Concurrent GE/SE BOLD-ASL acquisitions were performed during breath-holding (BH). We computed the CVR maps for the three signals. Results: The grey matter (GM) SE-BOLD CVR correlated more highly than GE-BOLD CVR with the ASL-derived GM CBF-CVR, across subjects and space. Impact: SE BOLD-fMRI may deliver a marker of CVR that resembles the physiological (CBF) CVR more closely than CVR based on GE BOLD, with the advantage of high signal-to-noise ratio compared to ASL.

Authors

Publication Details

Journal
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Published
2025-09-16
DOI
https://doi.org/10.58530/2025/1695
Primary Topic
Advanced MRI Techniques and Applications
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Measuring cerebrovascular reactivity: a comparison of Gradient-Echo and Spin-Echo BOLD with Arterial Spin Labelling

Maria Rita Carriero, Francesca Graziano, Stefano Censi, Antonio Maria Chiarelli et al.
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Advanced MRI Techniques and Applications
article

Measuring cerebrovascular reactivity: a comparison of Gradient-Echo and Spin-Echo BOLD with Arterial Spin Labelling

Maria Rita Carriero, Francesca Graziano, Stefano Censi, Antonio Maria Chiarelli, Alessandra Caporale, Michael Germuska, Ekaterina Bliakharskaia, Emma Biondetti, Richard G. Wise, Davide Di Censo, Fabrizio Fasano, Sara Pomante
article en

Abstract

Motivation: Gradient-echo (GE) BOLD-fMRI has been used with vasodilation to measure the cerebrovascular reactivity (CVR). However, the GE-BOLD signal is weighted by cerebral blood volume (CBV) in large veins. Spin-Echo (SE) BOLD fMRI is less sensitive to large veins and may deliver estimates closer to the physiological CVR. Goal(s): To compare GE-BOLD, SE-BOLD, and CBF based CVR measurements across subjects and across space. Approach: Concurrent GE/SE BOLD-ASL acquisitions were performed during breath-holding (BH). We computed the CVR maps for the three signals. Results: The grey matter (GM) SE-BOLD CVR correlated more highly than GE-BOLD CVR with the ASL-derived GM CBF-CVR, across subjects and space. Impact: SE BOLD-fMRI may deliver a marker of CVR that resembles the physiological (CBF) CVR more closely than CVR based on GE BOLD, with the advantage of high signal-to-noise ratio compared to ASL.

Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Openalex Percentile: Top 65%
Advanced MRI Techniques and Applications
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Measuring cerebrovascular reactivity: a comparison of Gradient-Echo and Spin-Echo BOLD with Arterial Spin Labelling — Maria Rita Carriero, Francesca Graziano, et al. · Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition (2025) | TGRS Research Map | TGRS