A porcine model of realistic closed-head impacts with multiple-timepoint MRI
Motivation: Mild traumatic brain injury (mTBI) is a global health challenge, yet its mechanism is not understood. Human post-impact imaging is multi-factorial and variable. Studies to unveil the local brain injury cascade are needed. Goal(s): To present a porcine model of realistic human-mimicking head impacts with multiple MRI timepoints and histologic validation. Approach: A linear impactor delivers a head impact leading to high rotational accelerations. We record biomechanics and perform detailed pre-/post-impact MR on a human scanner, ex vivo MR, coregistered histology, and finite-element modeling (FEM). Results: We identify injury on in vivo and ex vivo MRI, predict with FEM, and validate with pathology. Impact: Our novel large-animal linear-impact head impact model can detect injury with pre- and post-impact in vivo and ex vivo MRI, pathology, and finite-element modeling. This paradigm can uncover the microstructural, biomechanical, and molecular mechanism of head impact-induced brain injury.
Authors
- Michael Zeineh (ORCID: https://orcid.org/0000-0002-6940-9096)
- Susan S. Margulies (ORCID: https://orcid.org/0000-0002-3615-7902)
- Marios Georgiadis (ORCID: https://orcid.org/0000-0003-0733-4559)
- Jeffrey Nirschl (ORCID: https://orcid.org/0000-0001-6857-341X)
- Gerald Grant (ORCID: https://orcid.org/0000-0002-9680-741X)
- Xianghao Zhan (ORCID: https://orcid.org/0000-0002-7058-2603)
- Congyu Liao (ORCID: https://orcid.org/0000-0003-2270-276X)
- David B. Camarillo (ORCID: https://orcid.org/0000-0003-4965-2977)
- Marzieh Hajiaghamemar (ORCID: https://orcid.org/0000-0002-0232-2447)
- Hossein Moein Taghavi (ORCID: https://orcid.org/0000-0002-8585-1634)
- Kawin Setsompop (ORCID: https://orcid.org/0000-0003-0455-7634)
- Yixin Wang (ORCID: https://orcid.org/0000-0003-4324-2408)
- William Ho
- Jessica Towns
- Kathleen Heng
- Vahidullah Tac
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/1242
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00