Differential Cerebrovascular Reactivity in the Precuneus: A Resting-State fMRI Study of Alzheimer's Disease and Mild Cognitive Impairment
Motivation: The individual cerebral hemodynamics variations and their relationships with cognitive function are not fully understood for Alzheimer's disease (AD) spectrum disorders. Goal(s): To investigate changes in cerebrovascular reactivity (CVR) obtained by resting-state functional MRI (rs-fMRI) in patients with mild cognitive impairment (MCI) and AD. Approach: Rs-fMRI, which does not require engagement in a CO2-realted task, was utilized to assess CVR in patients with MCI and AD. Results: Significant changes were observed in the CVR of the precuneus (PCU) in patients with MCI and AD. CVR values showed positive correlation with cognitive function impairment. Impact: Cerebrovascular reactivity (CVR) obtained by rs-fMRI in the precuneus can reflect the cognitive function impairment in patients with MCI and AD, and might be a potential biomarker for assessing cognitive dysfunction.
Authors
- Luoyu Wang (ORCID: https://orcid.org/0000-0002-7780-7190)
- Zhongxiang Ding (ORCID: https://orcid.org/0000-0001-7691-5571)
- Xiaojun Tang (ORCID: https://orcid.org/0000-0003-3486-1020)
- Qingqing Wen
- Qi Feng (ORCID: https://orcid.org/0009-0009-9719-852X)
- Hanjun Hu (ORCID: https://orcid.org/0009-0002-4286-8337)
- Xiufang Xu (ORCID: https://orcid.org/0009-0004-8742-9009)
- Zhengluan Liao (ORCID: https://orcid.org/0000-0002-6114-6682)
- Yidi Zhu
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/1576
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00