A Gradient Echo-Spin Echo BOLD framework for quantitative mapping of OEF and CMRO2 with calibrated functional MRI
Motivation: Calibrated (c-)fMRI produces OEF and CMRO2 maps using BOLD-ASL recordings during isometabolic modulations of brain physiology. However, the method is limited by the low SNR of ASL. Goal(s): To develop and validate an easily implementable, high SNR, Gradient Echo-Spin Echo (GE/SE) BOLD c-fMRI approach for OEF estimation through a single vasodilatory stimulation, potentially not requiring ASL. Approach: We performed Monte Carlo simulations and GE/SE acquisitions during breath-holding to assess the method's feasibility. Results: GM OEF and CMRO2 maps were derived using the new framework, both with and without ASL information. Both measures correlated with macrovascular measures of OEF. Impact: The GE/SE BOLD calibrated fMRI framework appears feasible. It may allow for robust inference of OEF and CMRO2 maps through a single vasodilatory stimulus and without the need for functional ASL recordings.
Authors
- Francesca Graziano (ORCID: https://orcid.org/0000-0001-8754-6572)
- Maria Eugenia Caligiuri (ORCID: https://orcid.org/0000-0002-2030-5552)
- Stefano Censi (ORCID: https://orcid.org/0000-0002-3661-7737)
- Antonio Maria Chiarelli (ORCID: https://orcid.org/0000-0002-5347-8417)
- Alessandra Caporale (ORCID: https://orcid.org/0000-0002-2182-8312)
- Michael Germuska (ORCID: https://orcid.org/0000-0003-0580-4350)
- Ekaterina Bliakharskaia (ORCID: https://orcid.org/0009-0007-5943-9586)
- Emma Biondetti (ORCID: https://orcid.org/0000-0001-6727-0935)
- Richard G. Wise (ORCID: https://orcid.org/0000-0003-1700-2144)
- Davide Di Censo (ORCID: https://orcid.org/0000-0001-6116-607X)
- Fabrizio Fasano (ORCID: https://orcid.org/0000-0001-8396-4697)
- Sara Pomante
- Manuela Carriero
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0722
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00