Alterations in hypothalamus subunits morphology and functional connectivity in patients with adult-onset hypothyroidism

Motivation: Previous studies have reported alterations in brain structure and function associated with hypothyroidism. Whether there are alterations in the hypothalamus subunits is unknown. Goal(s): Our goal was to explore changes in the hypothalamus subunits of hypothyroidism using magnetic resonance imaging (MRI) technology. Approach: We assessed the intergroup differences of volumes and seed-based functional connectivity (FC) in hypothalamus subunits, as well as thyroid function indicators and neuropsychological scores. Moreover, a correlation analysis was performed to explore relationships between these factors. Results: The volume and seed-based FC of hypothalamus subunits changed in hypothyroidism patients. Furthermore, there was correlation between the volume and thyroid function indicators. Impact: This work may find alterations in the hypothalamus subunits at different phases of hypothyroidism, which may help us better understood the mechanisms underlying the brain damage caused by hypothyroidism.