Mathematical model of sciatic nerve regeneration: FA changes along the distal section relate to behavioral recovery

Motivation: Currently, there are no reliable, non-invasive biomarkers capable to early identify repair of severe peripheral nerve injuries cases that require additional surgical intervention Goal(s): FA monitors clinical axonal regeneration after surgical repair of traumatic peripheral nerve injuries. Approach: A novel mathematical model to identify and characterize multiple sections based on slice-wise FA values of the sciatic nerve following nerve repair provided an automated and consistent approach to identify cases that require surgical inventions. Results: Sections in close to the injury show higher correlation values (R2 = 0.713; p <0.001) with behavioral results than any other section of the distal region. Impact: FA close to the injury site shows great potential as a reliable biomarker for assessing nerve injury and postoperative recovery.

Authors

Publication Details

Journal
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Published
2025-09-16
DOI
https://doi.org/10.58530/2025/4945
Primary Topic
14-3-3 protein interactions
Type
article
Field-Weighted Citation Impact
0.00
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article

Mathematical model of sciatic nerve regeneration: FA changes along the distal section relate to behavioral recovery

Wesley P. Thayer, Sara C. Chaker, Richard Dortch, Barite Gutama et al.
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
14-3-3 protein interactions
article

Mathematical model of sciatic nerve regeneration: FA changes along the distal section relate to behavioral recovery

Wesley P. Thayer, Sara C. Chaker, Richard Dortch, Barite Gutama, Ricardo A. Torres‐Guzman, Anvith Reddy, Noah Alter, Yan Ling, Hüseyi̇n Karagöz, Ping Wang, Isaac Manzanera Esteve, Andrew James, Sharon K. Christopher, Benjamin L. Savitz, Ronald M. Cornely, Erin Abott
article en

Abstract

Motivation: Currently, there are no reliable, non-invasive biomarkers capable to early identify repair of severe peripheral nerve injuries cases that require additional surgical intervention Goal(s): FA monitors clinical axonal regeneration after surgical repair of traumatic peripheral nerve injuries. Approach: A novel mathematical model to identify and characterize multiple sections based on slice-wise FA values of the sciatic nerve following nerve repair provided an automated and consistent approach to identify cases that require surgical inventions. Results: Sections in close to the injury show higher correlation values (R2 = 0.713; p <0.001) with behavioral results than any other section of the distal region. Impact: FA close to the injury site shows great potential as a reliable biomarker for assessing nerve injury and postoperative recovery.

Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Openalex Percentile: Top 78%
14-3-3 protein interactions
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