Brain iron Deposition and Mitochondrial Dysfunction in Early-Stage Parkinson’s Disease

Motivation: The mechanisms behind pathological iron deposition in Parkinson's Disease (PD) are unclear, with mitochondrial dysfunction possibly driving this accumulation in the brain. Goal(s): To identify early biomarkers that better correlate with clinical symptoms in early-stage PD and to explore the links between mitochondrial dysfunction, iron deposition, and symptoms. Approach: Utilize 1H/31P MRI to assess iron deposition and phosphorus metabolites in the substantia nigra (SN) and putamen of early PD patients. Results: Early PD patients exhibit mitochondrial dysfunction, while significant iron deposition and abnormal volumes in the SN and putamen are not yet apparent. Impact: Mitochondrial dysfunction may precede brain iron deposition in PD, and has the potential to serve as a critical early indicator.