Correlation between T1/T2 mapping and cognitive impairment in Parkinson's disease based on Magic MRI quantitative imaging technique
Motivation: Cognitive impairment (PD-CI) is common in Parkinson's disease (PD), but reliable diagnostic biomarkers are lacking. Goal(s): To explore the correlation between gray matter and PD-CI using T1/T2 mapping with MAGiC and identify potential biomarkers. Approach: We applied the MAGiC technique to investigate T1/T2 mapping in PD patients and correlate it with cognitive performance. Results: Significant diagnostic value was found, with T1/T2 mapping in the left putamen serving as a potential biomarker for PD-CI. Impact: This study provides an objective imaging biomarker for cognitive impairment in Parkinson's disease, enhancing early detection and aiding in the development of personalized therapeutic strategies to manage PD-associated cognitive decline more effectively.
Authors
- Miao Chen (ORCID: https://orcid.org/0000-0002-7997-9594)
- Lizhi Xie (ORCID: https://orcid.org/0000-0002-4379-9348)
- Rui Zhang (ORCID: https://orcid.org/0000-0001-9418-0863)
- Wenjia Wang (ORCID: https://orcid.org/0000-0001-9219-0494)
- Gang Zhang (ORCID: https://orcid.org/0000-0002-6730-045X)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4705
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00