Quantification of Infrapatellar fat pad fibrosis using MRI-derived PDFF: A pathology-controlled study
Motivation: Fibrosis of the infrapatellar fat pad (IPFP) impacts knee osteoarthritis (KOA) progression [1]. Accurate assessment of IPFP fibrosis aids early intervention and treatment. Goal(s): To evaluate the diagnostic efficacy of proton density fat fraction (PDFF) and T2* measurements using mDixon-Quant technology in assessing IPFP fibrosis in KOA. Approach: We employed mDixon-Quant sequence to measure PDFF and T2*of IPFP, and evaluated correlations of the parameters with pathology-derived IPFP fibrosis degree and diagnostic efficacy. Results: PDFF and T2* measurements were strongly correlated with IPFP fibrosis and showed good diagnostic performance for IPFP fibrosis. Impact: PDFF and T2* measurements based on mDixon technology provide a non-invasive and quantitative assessment of IPFP fibrosis, especially PDFF.
Authors
- X.J. Zhang
- Qingzhu Wei (ORCID: https://orcid.org/0000-0001-9104-8058)
- Rongkai Zhang
- Qiushan Yu (ORCID: https://orcid.org/0009-0000-5938-9514)
- Hang Fang (ORCID: https://orcid.org/0000-0001-8321-4909)
- Kexin Jiang (ORCID: https://orcid.org/0009-0009-4312-6299)
- Chuan Huang (ORCID: https://orcid.org/0000-0001-6052-0663)
- Xiaodong Zhang (ORCID: https://orcid.org/0000-0002-4789-7324)
- Yanjun Chen (ORCID: https://orcid.org/0000-0003-0709-0208)
- Hongbo Zhang (ORCID: https://orcid.org/0000-0002-1071-4416)
- Beibei Zhou (ORCID: https://orcid.org/0000-0002-6288-8477)
- Tianyun Zhao
- Jinling Wu
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4690
- Primary Topic
- Musculoskeletal synovial abnormalities and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00