Quantitative IV Contrast-Enhanced MRI Measures Blood-to-CSF Exchange in the Human Brain over 24 Hours

Motivation: Previous studies have used intravenous contrast MRI to detect leakage into cerebral spinal fluid (CSF) spaces, yet more research is needed to establish the ideal timing and methodology. Goal(s): We aimed to determine the optimal time and MRI modalities for detecting contrast leakage into the CSF. Approach: Hourly scan sessions included quantitative T1 mapping, heavily T2w inversion recovery, and/or black blood (BB) sequences over a 24-hour period after contrast in healthy adults. Results: Contrast was detectable in CSF spaces on T1 mapping and within 1 hour, persisting for several hours. Possible leakage routes were identified with hT2W and black-blood (BB) imaging. Impact: Intravenous contrast leakage into CSF spaces was measured with quantitative and qualitative MRI, advancing methods to assess blood-to-CSF exchange. Contrast appeared within 1 hour and persisted for several hours, with potential leakage routes identified.