Instead of just undersampling, sample more and faster: 0.6mm isotropic MPRAGE at 7T in under 2 minutes
Motivation: Deep learning-based reconstructions could be used to further accelerate MR acquisitions by optimizing sequence parameters that reduce scan time, at the cost of reduced SNR, as an alternative to simply increasing undersampling factors. Goal(s): To compare a clinical MPRAGE protocol (CS x5, TA: 4min) at 7T with a x12 undersampled acquisition (Fast-Standard) and a time-matched protocol with x5 undersampling but higher turbo factor and optimized parameters to preserve contrast (Fast-Optimized). Approach: Reference and fast MPRAGE protocols were acquired in three subjects. Reconstructed images were compared qualitatively and quantitatively. Results: Fast-Optimized scans were more comparable to the reference than the Fast-Standard scans. Impact: This study demonstrates the effectiveness of using deep learning image reconstruction in combination with optimized sequence parameters for scan speed to further accelerate a clinical MPRAGE acquisition, in contrast to simply increasing undersampling factors.
Authors
- Tom Hilbert (ORCID: https://orcid.org/0000-0001-8207-4908)
- Patrick Alexander Liebig (ORCID: https://orcid.org/0000-0001-7342-3715)
- Dominik M. Nickel (ORCID: https://orcid.org/0000-0002-0360-7233)
- Bénédicte Maréchal (ORCID: https://orcid.org/0000-0001-7866-2854)
- Gian Franco Piredda (ORCID: https://orcid.org/0000-0002-8449-6634)
- Jocelyn Philippe (ORCID: https://orcid.org/0009-0009-5952-6107)
- Tommaso Di Noto (ORCID: https://orcid.org/0000-0002-5161-055X)
- Thomas Yu (ORCID: https://orcid.org/0000-0002-5841-0198)
- Antoine Klauser (ORCID: https://orcid.org/0000-0003-3019-9914)
- Tobias Kober (ORCID: https://orcid.org/0000-0001-7598-9456)
- Emilie Sleight (ORCID: https://orcid.org/0000-0003-0034-4578)
- Lina Bacha
- Natalia Pato Montemayor (ORCID: https://orcid.org/0009-0006-7212-1970)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/1372
- Primary Topic
- Cardiac Imaging and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00